منابع مشابه
Vaccine-induced HIV seropositivity/reactivity in noninfected HIV vaccine recipients.
CONTEXT Induction of protective anti-human immunodeficiency virus (HIV) immune responses is the goal of an HIV vaccine. However, this may cause a reactive result in routine HIV testing in the absence of HIV infection. OBJECTIVE To evaluate the frequency of vaccine-induced seropositivity/reactivity (VISP) in HIV vaccine trial participants. DESIGN, SETTING, AND PARTICIPANTS Three common US Fo...
متن کاملDesign and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine
BACKGROUND One of the big roadblocks in development of HIV-1/AIDS vaccines is the enormous diversity of HIV-1, which could limit the value of any HIV-1 vaccine candidate currently under test. METHODOLOGY AND FINDINGS To address the HIV-1 variation, we designed a novel T cell immunogen, designated HIV(CONSV), by assembling the 14 most conserved regions of the HIV-1 proteome into one chimaeric ...
متن کاملThe HIV vaccine saga
The development of a vaccine that can prevent infection by the Human immunodeficiency virus or prevent the Acquired Immunodeficiency Syndrome has remained elusive despite 20 years of scientific effort. This "Commentary" analyzes the reasons that the development of a vaccine has been so difficult, and proposes a plan to work towards an immunological approach to investigate the best vaccine candi...
متن کاملHIV Vaccine Development.
Several interesting new vaccine-related studies were presented at the 16th Conference on Retroviruses and Opportunistic Infections this year. Transmitted viruses appear to be derived from cell-free virus rather than cell-associated virus, at least in men who have sex with men. Follow-up studies from the Step (HIV Vaccine Trials Network 502) trial indicated that if individuals mounted certain va...
متن کاملHIV vaccine development.
For the past two decades, scientists have aggressively pursued the development of a vaccine against human immunodeficiency virus (HIV). The magnitude of this effort is unprecedented in the history of infectious diseases. However, difficulties in finding promising candidate vaccines have limited the number of clinical efficacy trials. The macaque model is well suited for the evaluation of potent...
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ژورنال
عنوان ژورنال: Molecular and Cellular Therapies
سال: 2018
ISSN: 2052-8426,2052-8426
DOI: 10.26781/2052-8426-2018-05